Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Background: In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine. Methods: Clinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published. Results: The expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm. Conclusions: We provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research

La vie de la lagune de Venise

Morandini Giuseppe. La vie de la lagune de Venise. In: Revue de géographie jointe au Bulletin de la Société de géographie de Lyon et de la région lyonnaise, vol. 25, n°1, 1950. pp. 9-19

Open-Source Multibody Analysis Software

This paper discusses the opportunity, for the community of multibody developers and users, of the availability of Open Source multibody analysis software implementations. The basic characteristics of such implementations are drawn, and a critical review of what is available is presented

Computational and Design Aspects in Multibody Software Development

It is often perceived that one key issue in the development of modern, highperformance numerical software is the need to find a good trade-off between modularity, extensibility and performance requirements. This paper discusses how the need to add real-time simulation capabilities to an existing general-purpose multibody analysis software, and the resulting need for performance improvements, pushed an overall performance improvement and capability extension within an existing modular generic programming environment

Aerodynamic models for cycloidal rotor analysis

Purpose-Few modeling approaches exist for cycloidal rotors because they are a prototypal technology. Thus, the purpose of this study was to develop new models for their analysis and validation. These models were used to analyze cycloidal rotors and a helicopter that uses them instead of a tail rotor. Design/methodology/approach-Three different models were developed to study the aerodynamic response of cycloidal rotors. They are a simplified analytical model resolved algebraically; a multibody model resolved numerically; and an unsteady computational fluid dynamics (CFD) model. The models were validated using data coming from three different experimental sources, each with rotor spans and radii of roughly 1 m. The CFD model was used to investigate the influence of rotor arms. The efficiency and the stability of the rotor in different configurations were studied. An aeroelastic multibody simulation was used to verify the influence of flexibility on the rotor response. Findings-The analyses suggested that cycloidal rotors can increase the efficiency of a helicopter at high velocities while flexibility reduces it and may lead to instabilities. Research limitations/implications-These models do not consider the effect of boundary layer friction on the trailing vortices generated by the rotor blades. Practical implications-These models allow a four-step aerodynamic optimization procedure. First, a range of optimized configurations is obtained by the analytical model. Second, the multibody model refines that range. Third, the CFD model detects eventual problematic blade interactions. Originality/value-The models presented should serve researchers and industrials looking for a means to measure the performance of cycloidal rotors concepts. The results presented also guide an initial cycloidal rotor design

Error rates during blood collection in emergency departments and outpatient clinics: Results of a prospective multicenter study.

Error rates during blood collection in emergency departments and outpatient clinics: Results of a prospective multicenter study

The Effectiveness of Paracetamol to Reduce the Post-Vaccination SARS-CoV-2 Adverse Effects in an Italian Vaccination Center

The arrival of specific vaccines was crucial for the eradication of COVID-19. Despite the security of the vaccination, the administration of COVID-19 mRNA vaccines often causes systemic side effects for a short time after the injection, such as headache, fatigue, fever, muscle pain and nausea. These side effects can limit the adherence to COVID-19 vaccines administration, especially in healthcare workers. This study aims to analyze the impact of the prophylactic use of paracetamol to reduce the post-vaccination Comirnaty/Pfizer adverse effects. The study took place at the San Giovanni Battista Hospital in Rome and included all hospital employees who received two doses of Pfizer-BioNTech. The vaccination health personnel recommended the preventive intake of 1 g of paracetamol before the inoculation of the vaccine and then every 6 h in the first 24 h. Information was collected through forms and subsequent telephone recall. A total of 403 volunteers were involved in the study, with 391 of them receiving two doses and twelve individuals only one dose of the vaccine. The main results demonstrated that the prophylactic therapy influenced the lower onset of asthenia in the first and second doses. However, there were no significant differences between the two groups in terms of fever, headache and localized pain. Paracetamol had a good impact on the side effect of COVID-19 vaccination, reducing asthenia in both doses and mitigating the total of symptoms during the second vaccination

Efficacy and toxicity of vinorelbine-carboplatin combination in the treatment of advanced adenocarcinoma or large-cell carcinoma of the lung.

Aims and background: The aim of the study was to assess the activity and toxicity of the vinorelbine-carboplatin combination in advanced adenocarcinoma or large-cell carcinoma of the lung. The new vinca derivative, vinorelbine, shows promising activity when combined with cisplatin, but toxicity of the combination is substantial. Methods: Accordingly, we substituted carboplatin for cisplatin in the combination in order to improve the therapeutic index. From March 1992 to March 1994, 55 untreated patients with undifferentiated unresectable or metastatic adenocarcinoma or large-cell carcinoma of the lung were recruited. The treatment consisted of a course of carboplatin (300 mg/m(2)) and vinorelbine (25 mg/mz) repeated every 4 weeks. The only grade 3 toxicity observed was 16 cases of grade 3 vomiting and 2 cases of grade 3 stomatitis. Results: The positive response rate was 40% (partial response, 22 patients). In conclusion, the vinorelbine-carboplatin combination may be regarded as an active, safe regimen for the palliative treatment of advanced adenocarcinoma or large-cell carcinoma of the lung